Hiii! She does not usually antagonize people just for fun, so Issy would have had to get on her bad side. BUT if Jade sees her as being either weak or a threat, she will speak up. She'd also take advantage if a situation arose where Issy had something Jade wanted or could help her get it. So long story short I am sorry in advance!

She will probably noooot pay much attention to Avery unless she voluntarily gets on her bad side

And she wonders why it's take so long for Penny to see the light and become rude to hide your own lack of confidence but hey. We will see how they do :)!